Vitenskapelig tittel:
Preventing Atopic Dermatitis and ALLergies

Allergic diseases affect 25-45% of the population, with huge individual and societal impact. To date, no primary prevention strategies are available. Although causes are unknown, environmental changes such as reduced microbial diversity and increased use of xenobiotics are likely to affect immune development by interacting with genes (epigenetic). Allergic and other non-communicable diseases (cardiovascular disease, obesity and diabetes) may stem from intrauterine and early life environment affecting immune- and organ development. Allergic diseases often start with atopic dermatitis and food allergy in infancy, followed by asthma and allergic rhinitis. PreventADALL is an international collaborative, innovative randomized controlled interventional birth cohort study testing if allergic diseases may be reduced by simple, low-cost primary prevention and identifying early origins of disease with data from 18 weeks pregnancy, biological sampling and long term characterisation of children.
(Prosjektleders prosjektbeskrivelse)

Ref. nr.: 2014/454 Prosjektstart: 03.03.2014 Prosjektslutt: 31.12.2044

Behandlingsstatus: Under behandling
Prosjektleder: Karin C. Lødrup Carlsen
Initiativtaker: Bidragsforskning

The present project is an ambitious, innovative and large multicentre, international study that will provide a number of sub-studies in the years to come. Thus, in order to ensure high quality data collection, biological samplings and provide interventions, the total budget from 2013-17 is approximately 90 mill NOK including all personnel and R&D costs.

At present (Februrary 2014). PreventADALL has sufficient funding to start data collection with the following support:

Helse SørØst:              9 mill NOK

UiO:                            0.6 mill NOK for lung function equipment and1 PhD

Thermo-Fisher:           IgE analyses through collaboration with Uppsala (professor Borres).

Østfold Hospital Trust: 50% PhD

Karolinska Institutet:

Diakonova:                  In kind and 40% nurse                       

The Norwegian Asthma and Allergy foundation: 75 000 NOK

Barnestiftelsen            80 000 NOK for bio-engineer

The Norwegian Directorate of Health: support for meetings

Stallergens                   Skin prick test allergen extracts provided for the study

Costs of ORAACLE personnel- and infrastructure in OUS/UiO, as well as personnel is not included in the present budget. Own funding for part of the interventions as well as some dedicated personnel is currently available within ORAACLE.

Forskningsdata: Registerdata, Humant biologisk materiale, Mennesker
Utvalg: Pasienter/klienter, Personer med mangelfull samtykkekompetanse, Fostre
Forskningsmetode:: Statistiske (kvantitative) analysemetoder
Antall forskningsdeltakere (Norge): 6300

Materiale fra biobank:
Behandlet i REK